CoCoFold2

Scalable latent refinement of diffusion-based protein structure predictions from limited-particle cryo-EM data.

CoCoFold2 connects a frozen Protenix-v1 diffusion prior to cryo-EM particle observations through target-specific latent refinement. The public software supports single-GPU and component-parallel refinement, structured experiment records, and CIF/PDB export.

Project website and tutorials · Source code

CoCoFold2 pipeline: latent refinement of a frozen diffusion prior against cryo-EM observations

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