CoCoFold

Fine-tuning AlphaFold with limited cryo-EM observations.

CoCoFold adapts AlphaFold using limited cryo-EM particles to refine atomic models when reconstructed maps are weak, anisotropic, or incomplete. It links predicted structures to experimental particles through differentiable projection and particle-level supervision, enabling target-specific correction while preserving the AlphaFold structural prior (Liao et al., 2026).

Benchmarks show improved accuracy and robustness in scarce-particle and missing-view regimes.

Paper · Code

CoCoFold pipeline

References

2026

  1. Commun. Chem.
    pipeline.png
    Fine-tuning AlphaFold with limited cryo-EM observations
    Junwen Liao, Dihan Zheng, Hui Zhang, and 3 more authors
    Communications Chemistry, 2026
    CoCoFold adapts AlphaFold using limited cryo-EM particles to refine atomic models when reconstructed maps are weak, anisotropic, or incomplete. It connects predicted structures to experimental particles through differentiable projection and particle-level supervision while preserving the AlphaFold structural prior.
    DOI Code